Table 8 The application of stem cells in clinic
From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Types of cells | Number of cases | Observation time | Results |
|---|---|---|---|---|---|
2011 | Orozco et al. [56] | Autologous BMSCs | 10 | 12 months | IVD water content↑, IVD height do not change |
2015 | Mochida et al. [57] | Autologous BMSCs + NP cells | 9 | 3 years | JOA↑ in 9 patients, no symptoms of low back pain, no adverse reactions |
2016 | Elabd et al. [58] | Autologous BMSCs under hypoxia | 5 | Long-term | Protrusions volume↓in 4 patients, IVD height keep or slightly↓ |
2017 | Centeno et al. [59] | Autologous BMSCs | 33 | 6 years | Pain↓, spinal function↑, disc prolapse↓ |
2017 | Pettine et al. [60] | Autologous BMSCs | 26 | 3 years | IVD function↑ in all patients in 1 year, only 6 patients need surgical treatment in 3 years |
2017 | Noriega et al. [62] | Allogeneic BMSCs | 12 | 12Â months | VAS, ODI and Pfirrmann levels all perform well |
2019 | Henriksson et al. [61] | Autologous BMSCs | 4 | 8 months | BMSCs differentiate into chondrocytes, ECM↑ |
2017 | Kumar et al. [77] | Human ADMSCs + HA | 10 | 12 months | VAS and ODI perform better over 5 patients, IVD water content↑ in 3 patients, no adverse reactions |
2014 | Pang et al. [96] | Human WJMSCs | 2 | 2Â years | VAS, ODI perform well |