Fig. 7
From: Attenuates of NAD+ impair BMSC osteogenesis and fracture repair through OXPHOS
Graphical abstract. Osteogenic committed BMSCs exhibit an elevated intracellular NAD+ level associated with an increased oxidative phosphorylation (OXPHOS) activity and a decreased glycolysis. Attenuates of NAD+ by FK866 diminish osteogenic commitment of BMSCs and impair bone fracture healing due to mitochondria dysfunction and reduced activity of OXPHOS. Additionally, deficiency of NAD+ impairs bone fracture healing