Fig. 2
MSCs attenuate hepatocyte necrosis and liver inflammation induced by APAP in a similar tendency to NAC. a Representative macroscopic view of livers from control mice or APAP mice administered PBS, MSCs (1.5 × 106) or NAC (300 mg/kg B.W.) at 24 h after APAP challenge (500 mg/kg B.W.). b Representative liver sections with HE staining from control mice or APAP mice administered PBS, MSCs (1.5 × 106) or NAC (300 mg/kg B.W.) at 24 h after APAP challenge. c Representative liver sections with TUNEL staining from control mice or APAP mice administered PBS, MSCs (1.5 × 106) or NAC (300 mg/kg B.W.) at 24 h after APAP challenge. d Serum NAPQI levels analysed by ELISA in control mice or APAP mice administered PBS, MSCs (1.5 × 106) or NAC (300 mg/kg B.W.) at 24 h after APAP challenge. e Flow cytometry analysis of the proportion of neutrophils and macrophages recruited to the liver from control mice or APAP mice administered PBS, MSCs (1.5 × 106) or NAC (300 mg/kg B.W.) at 24 h after APAP challenge