Table 2 The combination of cytotherapy and acupuncture in cerebral ischemia treatment
From: Combination of stem cell therapy and acupuncture to treat ischemic stroke: a prospective review
References | Cytotherapy and acupuncture intervention | Control group | Effect index | Comparison of effects between groups | Mechanism index |
|---|---|---|---|---|---|
[130] | HUCB-MSCs (1 × 106/10 µl, intracranial transplantation); EA (GV26, GV20, GV14, CV24, CV4, CV6; 30/100 Hz/5 V; 20 min; 7, 14, 28 days) | PBS group | Modified neurological severity score | EA + HUCB-MSCs > HUCB-MSCs > PBS | VEGF-positive cells↑ |
[131] | HUCB-MSCs (1 × 106/10 µl, intracranial transplantation); EA (GV26, GV20, GV14, CV24, CV4, CV6; 30/100 Hz/5V; 20 min; 7, 14, 28 days) | PBS group | Pathological lesion | EA + HUCB-MSCs > HUCB-MSCs > PBS | Cellular apoptosis↓ |
[118] | mBMSC (1 × 105/5 µl, intracranial transplantation); EA (GV14, GV20, 2Hz/2V; 20 min; 12 days) | MCAO group | Motor and cognitive dysfunctions Atrophic volume | mBMSC + EA > EA > mBMSC > MCAO | mBDNF↑, NT4↑ cAMP↑, pCREB↑ Proliferation of neural progenitor cells↑ |
[132] | TrkB-MSCs (1 × 106/2 μl, intracranial transplantation); EA (GV14, GV20, 2 Hz/2 V; 20 min; 10–22 days) | PBS group, MSCs group, MSCs + EA group | Motor and cognitive function | TrkB-MSCs + EA > TrkB-MSCs > MSCs + EA > MSCs > PBS | BDNF↑, NT4↑ Survival, differentiation and migration of TrkB-MSCs into mature neuronal cells↑ Activation of BDNF/NT4/TrkB Signaling pathway |