Table 2 Human NK cell markers and receptors
| Â | Ligands |
|---|---|
Activating receptors | Â |
CD94/NKG2C | HLA-E |
KIR2DL4 (CD158d) | HLA-G, HS |
KIR2DS1 (CD158h) | HLA-C |
KIR2DS2/3 (CD158j) | HLA-C |
KIR2DS4 (CD158i) | HLA-A, C |
KIR2DS5 (CD158f) | ???? |
KIR3DS1 (CD158e2) | HLA-B |
2B4 (CD244) | CD48 |
FCÉ£RIII (CD16) | IgG |
NKp46 (335) | Viral antigens |
NKp44 (336) | Viral antigens |
NKp30 (337) | B7-H6 |
NKG2D (CD314) | MIC-A, MIC-B, ULBPs |
DNAM-1 (CD226) | Nectin-2 (CD112) PVR (CD155) |
NKp80 | AICL (activation-induced C-type lectin) |
NKRP-1 (CD161) | LLT-1 |
Inhibitory receptors | Â |
NKG2A/CD94 | HLA-E |
KIR2DL1 (CD158a) | HLA-C2 |
KIR2DL2/3 (CD158b) | HLA-C1 |
KIR2DL4 (CD158d) | HLA-G |
KIR2DL5 (CD158f) | ???? |
KIR3DL1 (CD158e1) | HLA-B |
KIR3DL2 (CD158k) | HLA-A |
LIR-1 | HLA-A, -G |
TIM-3 | GAL-9 |
CEACAM1 | CEACAM1/5 |
PD1 (CD279) | PD1L(CD274 or B7-H1) |
KLRG-1 | Cadherins |
TIGIT | PVR, PVRL2 |
Death receptors and ligands | Ligands |
TRAIL (TNF-related apoptosis-inducing ligand or CD253) | DR4 (TRAIL-R1), DR5(TRAIL-R2) |
Fas ligand (CD95L) | CD95 |
Fas or Apo1 (CD95) | CD95L |
CD40L (CD154) | CD40 |
Other antigens | Â |
TNFRSF7 (CD27) | CD70 |
LAMP-1 (CD107a) | – |