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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Long non-coding RNA SNHG5 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-212-3p/GDF5/SMAD pathway

Fig. 9

SNHG5 promotes osteogenic differentiation. SNHG5 is regulated by transcription factor YY1 which directly binds to its promoter region to regulate osteogenesis. SNHG5 acts as a miR-212-3p sponge, which further directly targets GDF5 to activate the phosphorylation of Smad1/5/8 to regulate osteogenesis. GDF5, growth differentiation factor 5; OCN, osteocalcin; SNHG5, small nucleolar RNA host gene 5; YY1, Yin Yang 1

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Stem Cell Research & Therapy

ISSN: 1757-6512