Fig. 3

Viral load from day 1 (baseline) to 14 days after UC-MSC treatment. A–D Graphs representing relative viral quantification. Viral load was determined based on the relative expression of the viral gene RdRP in relation to the human POLR2B gene (normalizer). Viral gene expression gradually decreased in patient samples from day 1 (baseline) to day 14 (A, B). C, D After linearizing the data by the natural logarithm (ln (x)) and obtaining the linear equation, the angular coefficient of the viral load line (slope) and the coefficient of determination (R²) were established. C UC-MSC and D Placebo. The angular coefficient (slope) and R² of each patient are plotted in (E). Average of the angular coefficient of each group (F). Mean with SEM; Student's unpaired t test analysis. UC-MSC, umbilical cord mesenchymal stromal cell; ns, not significant