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Table 3 Values of PD

From: Systematic review and meta-analysis on the use of human platelet lysate for mesenchymal stem cell cultures: comparison with fetal bovine serum and considerations on the production protocol

Passage (P)

Total studies

ASC results

BMSC results

Overall

(a) Comparison: HPL 10% vs FBS 10%

P1

4 studies

ASC: 1 study, not useful data, BMSC: 3 studies with useful data

No useful data

74 participants

MD − 0.90 favor to HPL 10%, IC 95% − 2.35, − 0.55

I2 = 97%

74 participants

MD − 0.90 favor to HPL 10%, IC 95% − 2.35, − 0.55

I2 = 97%

P2

5 studies

ASC: 2 study, 1 with useful data; BMSC: 3 studies with useful data

30 participants

MD − 4.58 favor to HPL 10%, IC 95% − 7.15, − 2.01

I2 = not applicable

74 participants

MD − 2.76 favor to HPL 10%, IC 95% − 3.81, − 1.71

I2 = 88%

104 participants

MD − 2.97 favor to HPL 10%, IC 95% − 3.97, − 1.97

I2 = 79%

P3

5 studies

ASC: 2 study, 1 with useful data; BMSC: 3 studies, 2 with useful data

30 participants

MD − 7.45 favor to HPL 10%, IC 95% − 10.17, − 4.73

I2 = not applicable

74 participants

MD − 4.68 favor to HPL 10%, IC 95% − 6.05, − 3.31

I2 = 85%

104 participants

MD − 5.17 favor to HPL 10%, IC 95% − 6.62, − 3.72

I2 = 81%

P4

4 studies

ASC: 2 study, 1 with useful data; BMSC: 2 studies, 1 with useful data

30 participants

MD − 9.66 favor to HPL 10%, IC 95% − 12.38, − 6.94

I2 = not applicable

36 participants

MD − 7.16 favor to HPL 10%, IC 95% − 8.11, − 6.21

I2 = not applicable

66 participants

MD − 8.07 favor to HPL 10%, IC 95% − 10.43, − 5.71

I2 = 65%

P5

3 studies

ASC: 1 study with useful data; BMSC: 2 studies, 1 with useful data

14 participants

MD − 14.00 favor to HPL 10%, IC 95% − 16.47, − 11.53

I2 = not applicable

36 participants

MD − 10.29 favor to HPL 10%, IC 95% − 11.75, − 8.83

I2 = not applicable

50 participants

MD − 12.01 favor to HPL 10%, IC 95% − 15.63, − 8.38

I2 = 84%

P7

3 studies

ASC: 1 study with useful data; BMSC: 2 studies with useful data

10 participants

MD − 21.00 favor to HPL 10%, IC 95% − 25.96, − 16.04

I2 = not applicable

36 participants

MD − 9.63 favor to HPL 10%, IC 95% − 17.21, − 2.04

I2 = 98%

46 participants

MD − 13.10 favor to HPL 10%, IC 95% − 20.48, − 5.73

I2 = 97%

(b) Comparison: HPL 5% vs FBS 10%

P1

BMSC: 1 study

No useful data

24 participants

MD − 0.39 favor to HPL 5%, IC 95% − 0.51, − 0.27

I2 = not applicable

No pooled analyses available

P2

2 studies

ASC: 1 study with no useful data; BMSC: 1 studies with useful data

No useful data

24 participants

MD − 0.89 favor to HPL 5%, IC 95% − 1.07, − 0.71

I2 = not applicable

No pooled analyses available

P3

3 studies

ASC: 1 study with no useful data; BMSC: 2 studies with useful data

No useful data

42 participants

MD − 1.73 favor to HPL 5%, IC 95% − 3.34, − 0.11

I2 = 83%

No pooled analyses available