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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF

Fig. 4

The effect of ADSC-Exos on bone defect in rats. Histological staining of calvarial bone defects in rats using H&E staining (D) and aniline blue (E). F Semi-quantitative analysis of bone union by histological staining. Immunofluorescence staining of rats’ calvarial bone implanted with GNP hydrogel or exosome-loaded GNP hydrogel. iNOS and CD206 were used as markers of M1 and M2 macrophages and double stained with F4/80 (a marker of macrophages) at 4 and 8 weeks after implantation. A and B are iNOS and CD206 immunofluorescence staining of bone defect sections respectively. C Semi-quantitative statistics of iNOS and CD206 positive cells. The significance levels are indicated: ns: not significant, *P < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512