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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug

Fig. 1

Induction of retina-specific genes in human dermal fibroblasts derived from a healthy individual (N#3, open box) and an RP patient (Pt#1, closed box) by retroviral infection of genes for transcription factors CRX, RAX, NeuroD and OTX2. A RT-PCR analysis for phototransduction-related genes, blue opsin, S-antigen, rhodopsin, GNAT1, GNAT2, recoverin, in cultured human dermal fibroblasts (HDF). Vertical axis; relative expression, Horizontal axis; weeks after transduction. Columns represent mean ± SEM. All data points are overlaid. **p < 0.01; student’s t-test (n = 6 (blue opsin, S-antigen, recoverin), n = 3 (GNAT1, GNAT2). B Ratio of expression levels of rod photoreceptor- and cone photoreceptor-specific genes in photoreceptor-like cells (S-antigen vs blue opsin). Error bar: SEM. **p < 0.01; student’s t-test (n = 6)

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Stem Cell Research & Therapy

ISSN: 1757-6512