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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis pigmentosa

Fig. 7

Effect of transplanted cells on the expression of endogenous mouse genes in rd12 retina. A Expression of pro-inflammatory genes (Tnfα, Cd3e, Il-2, Il-1β, Il-6 and Ccl2) and anti-inflammatory genes (Il-4 and Il-10), B neuroprotective genes (Bdnf, Gdnf, Igf, Cntfra, Jak1, Jak2, Stat3a, Gfap, Vegf, p53, Egfr, Ras, Raf, Mek1, Mek2, Erk1, Erk2, and Fos), C retinal genes (Lhx2, Glul, Mki67, Plpp3, Atp1b1, Mitf, Pmel, Cd24, Serpinf1, Rcvrn, Crx, Rho, Six3, Otx2, Six6, Gnl3, Fabp7, Abcg2, Pcna, Rps27a, Nrl, Spon1, Ccn1, Gpnmb, Sulf2, Best1, Tfap2a, Gnat2, Gja1, S100Aa11, and Hes1) and D genes involved in early (S100b, Nestin, Blbp, Pax6, and Hes5), intermediate (Tuj1, Ncam, Rest, Tlx, Ascl1, Mcm2, and Sstr2) and late (Dcx, Prox1, Calretinin, NeuN, Calbindin, Pou4f2, and Tuc-4) stage of neurogenesis. All gene expression was normalized to Gapdh and β-Actin, and error bars represent the SEM of the triplicate experiment (**p ≤ 0.01)

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Stem Cell Research & Therapy

ISSN: 1757-6512