Fig. 4

Infusion of UCMSCs promotes restoration of pancreatic islet function in T2DM mice. a Immunofluorescence staining of insulin in pancreatic tissue. b Immunofluorescence staining of pancreatic tissue glycogen. c H&E staining of pancreas tissue sections. Scale bar 100 µm. d Immunohistochemical staining of pancreatic tissue TNF-α. e Immunohistochemical staining of pancreatic tissue IL-6. f Serum insulin release levels. g Insulin resistance levels. NC (normal control); T2DM (Type II diabetic mellitus); UCMSC (hUC-MSCs); Mel (melatonin). Data are mean ± SD of (n = 15); ^*P < 0.05; ^**P < 0.01; ^***P < 0.001