Table 1 Functions of LncRNAs and their RBPs in self-renewal and differentiation of stem cells

MEG3

EZH2

hDFSC

Promote the osteogenic differentiation of hDFSC

MEG3 interacts with EZH2, down-regulation of MEG3 or EZH2 reduces the occupation of H3K27me3 on the Wnt gene promoter

[51]

Oct4P4

SUV39H1 HMTase

mESC

Inhibit the self-renewal of mESC

OctP4 combines with SUV39, H1 and HMTase to form a complex, recruits H3K9me3 and HP1α to the Oct4 promoter region and results in Oct4 silencing

[52]

ES1, ES2, ES3

SUZ12 and Sox2

hESC

Maintain the pluripotency of hESC

ES1, ES2 and ES3 interact with SUZ12 and Sox2, which are the components of PRC2 complex

[53]

Linc1614

PRC2 complex and Sox2

mESC

Maintain the pluripotency of mESC

Linc1614 interacts with Sox2, recruits the PRC2 complex to T, Eomes, and Pitx2 and other developmental gene regions and inhibits their expression

[54]

LncPRESS1

SIRT6

mESC

Maintain the pluripotency of mESC

LncPRESS1 interacts with SIRT6 and inhibits SIRT6 from attaching to chromatin, maintaining the acetylation level of Histone H3K56 and H3K9 on the promoters of pluripotent genes such as Oct4 and Nanog

[55]

LBCS

hnRNPK and EZH2

BCSC

Inhibit the self-renewal of BCSC

LBCS binds hnRNPK and EZH2 to form the hnRNPK-EZH2 complex, guides the complex to the Sox2 promoter and H3K27me3 to inhibit Sox2 expression

[56]

LincU

Dusp9

mESC

Maintain the pluripotency of mESC

LincU binds and stabilizes ERK-specific phosphatase DUSP to restrict MAPK/ERK activity

[57]

Trincr1

Trim71

mESC

Promote the proliferation of mESC

Thoc5 regulates the export of Trincr1 to the cytoplasm, lncRNA Trincr1 binds to Trim71 in the cytoplasm, inhibits the activity of SHCBP1 and phosphorylates ERK and promotes the expression of ERK pathway target genes

[58]

Linc1557

STAT3

mESC

Promote the self-renewal of mESC

Linc1557 interacts with STAT3 through specific binding sites to regulate the stability of its mRNA, thus regulating the LIF/STAT3 signaling pathway

[60]

hFAST

β- TrCP

hESC

Maintain the pluripotency of hESC

hFAST binds to WD40 domain of β- TrCP, impedes the interaction between β- TrCP and phosphorylated β-catenin and promotes Wnt activity

[62]

LncR492

HuR

mESC

Inhibit the neuroectodermal differentiation of mESC

LncR492 interacts with HuR and activates Wnt signaling

[64]

TCF7

BAF170 and SWI/SNF complex

liver CSC

Promote the self-renewal of liver CSC

TCF binds to BAF170 and recruits the SWI/SNF complex to the TCF7 promoter to regulate its expression, leading to the activation of Wnt signaling

[65]

H19

EZH2

hDPSC

Promote the dentin differentiation and proliferation of hDPSC

H19 recruits EZH2 to the LATS1 promoter region to induce H3K27me3, inhibiting the expression of LATS1, blocking the activation of the Hippo-YAP signaling pathway

[68]

HAND2-AS1

INO80 complex

live CSC

Promote the self-renewal of liver CSC

HAND2-AS1 combines with INO80 complex to promote the expression of BMPR1A and activate the BMP signaling

[71]

MALAT1

SRSF2

hASC

promote the Proliferation of neurons in the brain injury site of hASC

MALAT1 promotes the splicing of PKCδII by binding with SRSF2

[73]

tsRMST

Nanog and SUZ12

hESC

Inhibit the differentiation of hESC

tsRMST interacts with Nanog and SUZ12 to form a complex and inhibits the expression of Wnt5A through differentiation-related transcription factors, and inhibits non-standard Wnt pathway

[79]

Pnky

PTBP1

NSC

Inhibit the differentiation of NSC

Pnky interacts with PTBP1 to maintain the stability of its mRNA

[91, 92]

ANCR

PTBP1

hAMSC

Inhibit the differentiation of hAMSC into DE cell

ANCR binds to PTBP1, promotes the interaction between PTBP1 and ID2 mRNA and enhances the stability of ID2 mRNA

[93]

KB-1980E6.3

IGF2BP1

BCSC

Promote the stemness and proliferation of BCSC

KB-1980E6.3 binds to IGF2BP1 to form a complex under the induction of HIF-1α to recognize and enhance the stability of c-myc mRNA

[94]