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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

Fig. 2

UC-MSC administration inhibits renal inflammation in DN rats. a Relative mRNA expression of IL-6, IL-1β, TNF-α, and IL-10 in the kidney from DN rats with or without UC-MSC administration. b Concentration of IL-1β in the kidney and serum as measured by ELISA. c Concentration of IL-10 in the kidney and serum as measured by ELISA (n = 5–8 rats/group). d Infiltrating neutrophils in the kidney as represented by Ly6G immunohistochemistry staining. e Infiltrating macrophages in the kidney as represented by F4/80 immunofluorescence staining. n = 3 rats/group, Scale bar: 100 µm. Data presented as mean ± SD of individuals included in each group. *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512