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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Assessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia

Fig. 8

Changes of inflammatory cytokine levels in mouse lung lysate (n = 6). On PND7, IL-1β (A) and TNF-α (B) levels were increased in injured group, and EVs normalized them to control levels, which is comparable to hAEC treatment. On PND14, IL-1β (C) and MIP-2 (D) levels were higher in preterm EV-treated group. E Levels of RANTES only increased in the hAEC treatment group, but not in the EV group. LIF (F), MCP-1 (G) and GM-CSF (H) levels were increased in the injured group, and both hAECs and term EVs reduced them to control levels. However, levels of LIF and MCP-1 remained higher in the preterm EV treatment group. (*p < 0.05, **p < 0.01, ***p < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512