Skip to main content
Fig. 16 | Stem Cell Research & Therapy

Fig. 16

From: Human umbilical cord-derived mesenchymal stromal cells ameliorate aging-associated skeletal muscle atrophy and dysfunction by modulating apoptosis and mitochondrial damage in SAMP10 mice

Fig. 16

Proposed mechanism of UC-MSC-mediated alleviation of muscle mass loss and dysfunction in a SAMP10 mouse model. UC-MSCs: umbilical cord-derived mesenchymal stromal cells, AMPK: adenosine monophosphate (AMP)-activated protein kinase, mTOR: mammalian target rapamycin, HGF: hepatocyte growth factor, VEGF: vascular endothelial cell growth factor, PGC-1α: peroxisome proliferator-activator-γ coactivator-1α, MCP-1: monocyte chemoattractant protein-1, COX-IV, cytochrome c oxidase subunit 4; GLUT-4, glucose transporter-4; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; CatK, cathepsin K; PCNA, proliferating cell nuclear antigen; TNF-α: tumor necrosis factor-alpha, TLR-2, toll-like receptor-2

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512