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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment

Fig. 1

Histological and molecular changes in periodontal tissue under OTM. Adult male Sprague–Dawley rats were used for the OTM model. A Application of orthodontic force using nickel-titanium coil spring. B Micro-CT show tooth movement of the control group(NC) and the tooth movement group(OTM). C Immunohistochemical staining of HIF-1α in the PDL of the mesial compression side of the molars. The images in the second raw refer to the black frames in the first raw. The quantitative results are presented beside. D qRT-PCR results show the mRNA expression of SNHG8, HIF-1α,IL-1β and TNF-α in the periodontal tissue of the first molars. Data shown are mean ± SD(n = 12). (Analysis of variance *p < 0.05; ***p < 0.001; ****p < 0.0001)

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Stem Cell Research & Therapy

ISSN: 1757-6512