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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment

Fig. 2

Mechanical force upregulates hypoxia and inflammation and downregulates SNHG8 in PDLCs. Cells were subjected to static compressive force for 0, 6,12, 24 h. A Schematic diagram of compressive force applied. B qRT-PCR results show the mRNA expression of SNHG8, HIF-1α, IL-1β, IL-6, IL-8 and TNF-α in PDLCs after application of force. C Western blot analyses of HIF-1α, p65, phos-p65 and IκBα after application of force. Histograms show the quantification of the band intensities. (Analysis of variance *p < 0.05; **p < 0.01; NS: nonsignificance, p > 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512