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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment

Fig. 4

RNA sequencing following transfection with SNHG8. A Volcano plot of differentially expressed mRNAs in the control and SNHG8 groups. Red points: upregulated mRNAs; blue points: downregulated mRNAs. B The top 20 of gene ontology (GO) enrichment. Red frame: the altered mRNAs are enriched in cellular response to hypoxia. C Histograms show the genes related to the cellular response to hypoxia among the downregulated genes. D qRT-PCR results show that SNHG8 functions in the nucleus. E qRT-PCR results show the mRNA expression of six HIF-1-mediated downstream genes, AQP1, RORA, RGCC, VEGFA, PTGIS, and PPARGC1A in the control group, SNHG8 group and SNHG8 supplemented with DMOG group. DMOG: dimethyloxalylglycine, an HIF-1α agonist. (Analysis of variance **p < 0.01; ***p < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512