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Table 3 Percentage of deaths in IV-studied groups in subacute and subchronic phase

From: Standard toxicity study of clinical-grade allogeneic human bone marrow-derived clonal mesenchymal stromal cells

Groups

Number of animals per group

Dose levels

Mortality (%)

Subacute phase

Subchronic phase

Subacute phase

Subchronic phase

Control

12 (6 males and 6 females)

12 (6 males and 6 females)

500 μl NS

0

8.3 (one male)

Treatment

12 (6 males and 6 females)

12 (6 males and 6 females)

6 × 106 cells/kg in 500 μl NS + 1 μl Rock inhibitor

0

0

  1. IV intravenous, NS normal saline