Fig. 1
From: Potency assays for human adipose-derived stem cells as a medicinal product toward wound healing
Confirmed MeA of adipose-derived stem cells in the different phases of wound healing. Adipose-derived stem cells (ASCs) have distinct mode of actions (MoA) in each stage of wound healing, however the mechanism of action (MeA) by which they execute these are still not fully validated. In the Inflammation stage it has been confirmed that ASCs secrete IDO, and through that having an immunosuppressive effect on T cell infiltration and PBMC proliferation. In the proliferation stages, ASCs are through galectin-1, MALAT1, and VEGF confirmed to increase re-epithelialization, ECM regulation, and angiogenesis, respectively. However, in the remodeling stage no factors have been verified for the different MoAs, including reducing scar formation, reducing scar contraction, increasing the ratio of type I/III collagen, and a general ECM modulation. IDO, indoleamine 2,3-dioxygenase; PBMC, peripheral blood mononuclear cell; MALAT1, mucosa-associated lymphoid tissue lymphoma translocation protein 1; VEGF, vascular endothelial growth factor; ECM, extracellular matrix