Potency assays for human adipose-derived stem cells as a medicinal product toward wound healing

Table 1 An overview of in vivo biological potency assays testing the effects of hASCs in animal models of wound healing

Phase	MoA	Animal model	References
Inflammation	↓ T cell infiltration, ↓ pro-inflammatory genes	SCID mice	[25]
	↓ T cell infiltration	Balb/C mice	[45]
Proliferation
Granulation tissue formation	↑ collagenous fibers	Kunming mice	[46]
		Balb/c mice	[38]
Vascularization	↑ vascularity	Balb/c nude mice	[47]
		Kunming mice	[46]
		Diabetic mice	[48]
		CD1 athymic nude mice	[49]
Re-epithelialization	↑ re-epithelization	Kunming mice	[46]
		Diabetic mice	[48]
Remodeling	↓ scar formation	Kunming mice	[46]
	↑ collagenous fibers	Balb/c mice	[38]
	Flattened epidermis, ↑ bundles of collagen III, ↑ collagen III to I ratio, reticular collagen organization	Balb/c mice	[42]

hASCs, human adipose-derived stem cells; MoA, mode of action; ↑, increased; ↓, decreased

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