Table 6 Confirmed mechanisms of action of hASCs
From: Potency assays for human adipose-derived stem cells as a medicinal product toward wound healing
MoA | MeA | Confirmed by | References |
|---|---|---|---|
Proliferation of PBMCs | Secretion of IDO | IDO activity inhibitor L-tryptophan | [93] |
| Â | Â | IDO activity inhibitor Kynurenine | [93] |
| Â | Â | IDO activity inhibitor epacadostat | [98] |
Infiltration of T cells | Secretion of IDO | IDO activity inhibitor L-tryptophan | [97] |
Migration of fibroblasts | Expression of MALAT1 | ASO transfection | [60] |
Endothelial sprouting | Secretion of VEGF | VEGFR inhibitor SU5416 | [72] |
Migration of keratinocytes | Secretion of galectin-1 | Neutralizing antibody | [58] |