Fig. 6

IL-6 enhances cutaneous wound healing in mice. A Gross view of wounds in the DMEM, S-siNC-MSCs, S-siNC-IT MSCs, S-siIL-6-IT MSCs, S-siIL-6-IT MSCs-recIL-6 treatment groups at days 0, 2, 4, and 8 post administration. B The rate of wound closure in wounds receiving different treatments at the indicated times. C Representative images of Masson’s trichrome staining after wound treatment at day 3. The granulation tissue (blue) is characterized by a large amount of collagen deposition. Muscle under the wounds is stained red. Scale bar = 100 µm. D Quantification of granulation tissue thickness. E H&E staining of wound sections at day 7 post administration. Red arrows indicate tips of the epithelium tongue. Data are representative of four independent experiments. Scale bar = 100 μm. n = 4 mice for each group, *P < 0.05; **P < 0.001; and ***P < 0.0001