Fig. 3
From: Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway
Declines in EGFR expression restricted wound healing and EGF efficacy in aged epidermis. a Gross view of wounds with different treatments post-wounding. N = 6. *P < 0.05, **P < 0.01 vs. the control group. b 1 mm epidermis samples from the wound margin of 2 M SD rats were analyzed by Western Blot. N = 6. *P < 0.05, **P < 0.01 vs. the control group. c We generated 10 mm full-thickness cutaneous wounds on the backs of 2 M, 17 M and 23 M rats, and animals of each age were randomly divided into control group and EGF-treated group that received a total 200 μL drug (PBS, 10 μg/mL EGF) sprayed evenly on the wound everyday post wounding. N = 6. *P < 0.05 and **P < 0.01 were used to indicate the difference between the control group and the EGF-treated group within the rats of each age at time points. #P < 0.05 and ##P < 0.01 were used to indicate the difference between the control group of 2 M, 17 M and 23 M rats at time-points