Fig. 3

Forest plot of Subjects with AEs and SAEs. There was no statistical difference in the number of patients with AEs or SAEs after MSCs treatment compared with placebo. Three studies related to SAEs have some heterogeneity, and a random-effects model was used for statistical analysis. In the plane rectangular coordinate system, the forest plot takes a vertical invalid line (scale of abscissa is 0) as the center, describes the effect quantity and 95% CI of each study by using multiple line segments parallel to the horizontal axis, and describes the effect quantity and confidence interval of multiple studies by using a diamond. AEs, adverse events; SAEs, serious adverse events; MSCs, mesenchymal stem cells; CI, confidence interval