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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: TSG-6 released from adipose stem cells-derived small extracellular vesicle protects against spinal cord ischemia reperfusion injury by inhibiting endoplasmic reticulum stress

Fig. 1

ADSC-sEVs were internalized by neurons to inhibit apoptosis in vitro. a Representative images of neurons incubated with Dil-labeled sEVs. The nuclei of neuron were stained with DAPI (blue). b TUNEL staining (red) showing apoptotic rate of primary neurons. Cell nuclei were counterstained with DAPI (blue). c Annexin V-FITC/PI double staining was determined by flow cytometry. d Quantitative estimation of the apoptotic rate in each group. ADSC-sEVs significantly reduced OGD/R-induced apoptosis. e Quantitative estimation of apoptosis rate of neurons with flow cytometry. f Expression of apoptosis-related proteins as measured by Western blotting analysis. g Relative expression levels of apoptosis-related proteins normalized to GAPDH. *p < 0.05 compared with the control group, #p < 0.05 compared with the OGD/R group

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Stem Cell Research & Therapy

ISSN: 1757-6512