Table 3 Stem cells-derived exosomes application in ICH rats
From: Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
Source | Type of ICH | Contents | Involved pathway | Main results |
|---|---|---|---|---|
AD-MSCs [133] | Col IV | – | – | Improved neurological function, the integrity of fiber tracts, axonal sprout and lesion size |
MiR-21-BM-MSCs [126] | Col VII | MiR-21-exosomes | NF-κB | MiR-21 improved the survival rate of MSCs; Exosomes transportation miR-21 reduced neuronal apoptosis; Promoted the recovery of nervous function |
MiR-133b-BM-MSCs [134] | ABI | MiR-133b-exosomes | ERK1/2/CREB | Exerted neuroprotective effect; Reduced the apoptosis of nerve cells and neurodegeneration |
MiR-146a-5p -BM-MSCs [135] | Col IV | MiR-146a-5p-exosomes | NF-κB | Improved neurological function; Reduced the apoptosis of nerve cells and neurodegeneration; Inhibited inflammation and the M1 polarization of microglia after ICH |
BM-MSCs [136] | ABI | Exosomes | – | Enhanced functional recovery; Facilitated endogenous neurogenesis and angiogenesis |