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Table 3 Stem cells-derived exosomes application in ICH rats

From: Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update

Source Type of ICH Contents Involved pathway Main results
AD-MSCs [133] Col IV Improved neurological function, the integrity of fiber tracts, axonal sprout and lesion size
MiR-21-BM-MSCs [126] Col VII MiR-21-exosomes NF-κB MiR-21 improved the survival rate of MSCs; Exosomes transportation miR-21 reduced neuronal apoptosis; Promoted the recovery of nervous function
MiR-133b-BM-MSCs [134] ABI MiR-133b-exosomes ERK1/2/CREB Exerted neuroprotective effect; Reduced the apoptosis of nerve cells and neurodegeneration
MiR-146a-5p -BM-MSCs [135] Col IV MiR-146a-5p-exosomes NF-κB Improved neurological function; Reduced the apoptosis of nerve cells and neurodegeneration; Inhibited inflammation and the M1 polarization of microglia after ICH
BM-MSCs [136] ABI Exosomes Enhanced functional recovery; Facilitated endogenous neurogenesis and angiogenesis
  1. AD-MSCs adipose-derived mesenchymal stem cells, BM-MSCs bone narrow mesenchymal stem cells, Col collagenase, ABI autologous blood injection, ICH intracerebral hemorrhage