Table 1 Main therapeutic strategies for T1D in current clinical trials
Therapeutic strategy | Sponsor | Trial status | Phase | Country | Identifier | Outcome |
|---|---|---|---|---|---|---|
Allogeneic Wharton´s jelly derived mesenchymal stromal cells transplantation | NextCell Pharma | Completed | Phase I/II | Sweden | NCT03406585 (Clinical Trials) | Preserved β-cell function in newly diagnosed T1D patients |
Allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) transplantation | Medical University of South Carolina | Ongoing | Phase I | USA | NCT04061746 (Clinical Trials) | – |
Allogeneic adipose-derived mesenchymal stromal cells and autologous bone marrow mononuclear cells co-transplantation | Sophia Al-Adwan (University of Jordan) | Ongoing | Phase I | Jordan | NCT02940418 (Clinical Trials) | – |
Ex vivo cultured adult allogeneic MSCs (PROCHYMAL) transplantation | Mesoblast Inc | Completed | Phase II | USA | NCT00690066 (Clinical Trials) | No results posted |
Autologous bone marrow-derived mesenchymal stromal cells transplantation | Royan Institute | Ongoing | Phase I/II | Iran | NCT04078308 (Clinical Trials) | – |
Dental Pulp MSCs from human exfoliated teeth transplantation | Shanghai CAR-T Biotechnology Co., Ltd | Ongoing | Phase I | China | NCT03912480 (Clinical Trials) | – |
Autologous hematopoietic stem cells transplantation | Dr. Olga Graciela Cantu Rodriguez (Dr. Jose E. Gonzalez University Hospital) | Completed | Phase I/II | Mexico | NCT01121029 (Clinical Trials) | No results posted |
Autologous hematopoietic stem cells transplantation with immunosuppression regimen | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Completed | Phase II | China | NCT01341899 (Clinical Trials) | Modulated lymphocytes and preserved β-cell function in Chinese patients with newly onset of type 1 diabetes and diabetic ketoacidosis |
Bone marrow-derived hematopoietic stem cells transplantation with immunosuppression regimen | University of São Paulo Ribeirão Preto Medical School | Completed | Phase I/II | Brazil | NCT00315133 (Clinical Trials) | No results posted |
Reversal of Type 1 Diabetes in Children by Stem Cell Educator Therapy | Tianhe Stem Cell Biotechnologies Inc | Ongoing | Phase I/II | China | NCT01996228 (Clinical Trials) | – |
Autologous expanded progeny of an adult CD34 + stem cell subset (InsulinCytes) transplantation | Imperial College of London | Completed | Phase I | UK | NCT00788827 (Clinical Trials) | No difference was observed in patients' conditions after treatment |
Implantable device with insulin-producing cells transplantation under immunosuppression regimen | Sernova Co | Ongoing | Phase I/II | USA | NCT03513939 (Clinical Trials) | – |
Human allogeneic pancreatic islet cells transplantation with steroid-free immunosuppression regimen (Edmonton Protocol) | Emory University | Completed | Phase II | USA | NCT00133809 (Clinical Trials) | 62.5% insulin-independent subjects one year after intervention 50% subjects with HbA1C ≤ 6.5% after 5 years and 37,5% subjects exhibiting fasting C-peptide levels ≥ 0.5 ng/mL after 5 years |
Pancreatic islet cells endoscopic transplantation into the gastrointestinal sub-mucosa with immunosuppressive regimen | University of California (San Francisco) | Ongoing | Phase I | USA | NCT02402439 (Clinical Trials) | – |
Human allogeneic pancreatic islet cells transplantation under immunosuppression regimen | National Institute of Allergy and Infectious Diseases (NIAID) | Completed | Phase III | USA | NCT00434811 (Clinical Trials) | No results posted |
Sequential transplantation of umbilical cord-derived blood stem cells and pancreatic islet cells | Children’s Hospital of Fudan University | Ongoing | NA | China | NCT03835312 (Clinical Trials) | – |
Allogeneic islet cells transplantation into the omental pouch | University of Alberta | Completed | Phase I/II | Canada | NCT02821026 (Clinical Trials) | No results posted |
Allogeneic pancreatic islet cells and parathyroid gland co-transplantation | Peter Stock (University of California, San Francisco) | Ongoing | Phase I/II | USA | NCT03977662 (Clinical Trials) | – |
Encapsulated stem cell-derived pancreatic islet cells transplantation | ViaCyte | Completed | Phase I | Canada | NCT03162926 (Clinical Trials) | No results posted |
A Safety, Tolerability and Efficacy Study of VX-880 | Vertex Pharmaceuticals | Ongoing | Phase I/II | USA | NCT04786262 (Clinical Trials) | – |