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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo

Fig. 3

BM-MSCs treated with SMG-ECM formed cell aggregates expressing SG epithelial cell-related transcripts. BM-MSCs were either untreated (untreated) or treated with SMG-ECM or BM-ECM, as described in Fig. 2, for 7 or 14 days. RT-PCR was used to measure the expression of SG epithelial cell lineage markers in untreated cells or cells treated with SMG-ECM or BM-ECM and formed aggregates (Agg/SMG-ECM or Agg/BM-ECM) or a monolayer (Mono/SMG-ECM or Mono/BM-ECM). Data are the mean ± SD from a representative experiment. *p < 0.05, versus all other treatment groups on day 7; **p < 0.001, versus all other treatment groups on day 14. Each experiment contained 3 replicates, and each experiment was repeated 4–6 times with cells from different donors

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Stem Cell Research & Therapy

ISSN: 1757-6512