Fig. 5

Histological analysis of the subcutaneous implantation sites in normal mice, hematoxylin–eosin, scale bar—100 µm. A, C, E The implant (highlighted with dotted line) consisted of the decellularized matrix represented by extracellular components of the cartilaginous ring and submucosa. On the side facing the epidermis, the implant contained wells (about 100 µm deep). There were no signs of the foreign body tissue reaction. B, D, F The implant consisted of the decellularized matrix seeded with cells (cartilage construct). The connective tissue capsule (*) was formed around the construct. There were no signs of the foreign body tissue reaction