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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Prostaglandin E1 reduces apoptosis and improves the homing of mesenchymal stem cells in pulmonary arterial hypertension by regulating hypoxia-inducible factor 1 alpha

Fig. 3

A Results of the flow cytometry experiment showed that MSC apoptosis increased in response to treatment with H2O2. PGE1 treatment reduced MSC apoptosis, whereas YC-1 blocked the protective effect of PGE1. B Results of the western blotting experiment showed that the protein levels of Bcl-2 in MSCs decreased in response to treatment with H2O2. Moreover, PGE1 increased the protein levels of HIF-1α, Bcl-2, and CXCR4, and YC-1 reversed the effects of PGE1 (P < 0.05). Bcl-2 B-cell lymphoma 2, CXCR4 C-X-C chemokine receptor 4, HIF-1α hypoxia-inducible factor 1 alpha, MSC mesenchymal stem cell, PGE1 prostaglandin E1

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Stem Cell Research & Therapy

ISSN: 1757-6512