Fig. 7
H2O2-HUVEC-Exos enhanced the survival of skin flaps. A Schematic representation of the experimental procedures. B Quantitative analysis of fluorescent signals intensity in control, HUVEC-Exos, si-NEAT1-HUVEC-Exos, H2O2-HUVEC-Exos and si-NEAT1-H2O2-HUVEC-Exos groups at 30 min, 4 h, 3 d and 7 d, n = 5 in each group. ns. P > 0.05, * P < 0.05. C The representative in vivo fluorescence imaging in different groups at 30 min, 4 h, 3 d and 7 d after the injection of HUVEC-Exos, si-NEAT1-HUVEC-Exos, H2O2-HUVEC-Exos, si-NEAT1-H2O2-HUVEC-Exos or PBS. D Representative gross appearance of viable and necrotic skin regions in skin flap treated in control, HUVEC-Exos, si-NEAT1-HUVEC-Exos, H2O2-HUVEC-Exos, si-NEAT1-H2O2-HUVEC-Exos groups. E Quantification of percentages of survival area on day 14. * P < 0.05, ** P < 0.01, **** P < 0.0001 vs. control group