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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Meiosis resumption in human primordial germ cells from induced pluripotent stem cells by in vitro activation and reconstruction of ovarian nests

Fig. 5

Human activated PGC-derived oogonia displayed a state of meiotic recombination and resumed meiosis. A Human activated PGC-derived cells upregulated genes for oogonia and gonocytes (DAZL and DDX4) and genes for meiosis (SYCP3 and REC8). B In all 50 mitotic phases, 2 haploid karyotypes were found. C Chromosome pairing and crossover occurred in the mixture of human activated PGCs/oogonia and fetal somatic cells after transplantation into the ovarian nests of SCID mice

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Stem Cell Research & Therapy

ISSN: 1757-6512