Fig. 2
Aβ1-42-induced memory impairment and senile plaques (A–C). Passive avoidance test (A). Evaluating the learning and memory following Aβ 1–42 injection demonstrated that the step-through latency assessment during the retention trial decreased in the AD mice compared to the control group (p < 0.001). Thioflavin-S staining (B–C). Histologic data showed that the number of senile plaques was enhanced in the AD + vehicle group in comparison with the control one (p < 0.001). One-way ANOVA and Tukey post hoc analysis. *p < 0.05; **p < 0.01; ***p < 0.001; and ****p < 0.0001. AD, Alzheimer’s disease. Morris water maze test (D–F). NTF-SCs transplantation decreased the escape latency over 5 days compared to the AD + Vehicle group (D). NTF-SCs were the potential to reduce the cumulative distance to the platform in AD mice compared to the AD + Vehicle group (E). Moreover, the time spent in target quadrants was reduced in AD mice and transplantation of NTF-SCs ameliorated the Aβ 1–42 adverse effects (F)