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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells improve liver fibrosis and protect hepatocytes by promoting microRNA-148a-5p-mediated inhibition of Notch signaling pathway

Fig. 5

HUC-MSCs inhibit hepatocellular apoptosis and enhance liver regeneration by up-regulating miR-148-5p in mice. a The expression levels of miR-148-5p in hepatocytes extracted from mouse hepatic tissues of sham, BDL, and BDL + MSC groups. b Immunohistochemical staining of Ki-67 in liver tissues of the three groups. c TUNEL staining of liver sections from the three groups. d Serum levels of ALT, AST, TBIL, and albumin in the three groups. Each experiment was repeated three times. *P < 0.05, **P < 0.01, ***P < 0.001 and n.s. not significant. HUC-MSCs human umbilical cord mesenchymal stem cells; ALT alanine aminotransferase; AST aspartate aminotransferase; TBIL total bilirubin

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Stem Cell Research & Therapy

ISSN: 1757-6512