Fig. 4

ADSC-exo ameliorated inflammation in Ang II-pretreated Raw264.7 by modulating TXNIP. A–C Western blot and RT-qPCR analyses were performed to evaluate the level of an overexpressed TXNIP in Raw264.7 cells. D–E ADSC-exos reduced the inflammasome-related gene expression of Ang II-treated Raw264.7 cells, while gain of TXNIP counteracted such inhibitory effects of ADSC-exos. F–G ELISA analysis of IL-18 and IL-1β. Repetition = 3. The one-way ANOVA and two-tailed Student’s t-test were performed to compare data between groups. *P value < 0.05, **P value < 0.01, ***P value < 0.001