Fig. 7

ADSC-exo-carried miR-17-5p inactivated TXNIP-NLRP3 inflammasome. A–C The protein levels of TXNIP, NLRP3, cleaved-caspase-1, IL-18, and IL-1β in Ang II-induced AAA determined using western blot and RT-qPCR. D ELISA analysis of IL-18 and IL-1β in mice serum. E–F Immunofluorescence analysis of TXNIP positive macrophages in different groups. Scale bar: 50 μm. G–I The protein levels of TXNIP, NLRP3, cleaved-caspase-1, IL-18, and IL-1β in Ang II-treated Raw264.7 cells were evaluated by western blot and RT-qPCR analyses. J ELISA analysis of IL-18 and IL-1β in the supernatant of Raw264.7 cells. Repetition = 3. The one-way ANOVA was performed to compare data between groups. *P value < 0.05, **P value < 0.01, ***P value < 0.001