Table 2 Identified tECM proteins (< 100 kDa)
Protein name | Gene symbol | Category | Molecular weight (kDa) | Isoelectric point (pI) | Number of peptides | Sequence coverage (%) |
|---|---|---|---|---|---|---|
Keratocan | KERA | Proteoglycans | 40.4 | 6.8 | 14 | 36.53 |
Prolargin | PRELP | Proteoglycans | 43.7 | 9.6 | 11 | 31.60 |
Decorin | DCN | Proteoglycans | 39.9 | 8.7 | 11 | 30.07 |
Vimentin | VIM | Unclassified | 53.7 | 5.0 | 10 | 24.60 |
Fibromodulin | FMOD | Proteoglycans | 43.0 | 5.6 | 10 | 32.20 |
Actin, alpha cardiac muscle 1 | ACTC1 | Actin-related proteins | 42.0 | 5.2 | 10 | 37.70 |
Actin, alpha skeletal muscle | ACTA1 | Actin-related proteins | 42.0 | 5.2 | 10 | 33.93 |
Actin, aortic smooth muscle | ACTA2 | Actin-related proteins | 42.0 | 5.2 | 9 | 29.20 |
Biglycan | BGN | Proteoglycans | 41.5 | 6.8 | 7 | 23.30 |
Actin, cytoplasmic 1 | ACTB | Actin-related proteins | 41.7 | 5.3 | 7 | 23.83 |
Alpha-actinin-2 | ACTN2 | Unclassified | 103.7 | 5.3 | 7 | 8.95 |
Mimecan | OGN | Proteoglycans | 34.2 | 5.4 | 6 | 17.97 |
Prelamin-A/C | LMNA | Unclassified | 74.2 | 6.7 | 6 | 9.60 |
Angiopoietin-related protein 7 | ANGPTL7 | Secreted Factors | 39.4 | 7.6 | 5 | 17.27 |
Annexin A2 | ANXA2 | ECM-affiliated Proteins | 38.6 | 6.5 | 4 | 16.03 |
Thrombospondin-4 | THBS4 | ECM Glycoproteins | 105.9 | 4.4 | 4 | 5.87 |
Cartilage oligomeric matrix protein | COMP | ECM Glycoproteins | 82.3 | 4.4 | 4 | 8.03 |
Transforming growth factor-beta-induced protein ig-h3 | TGFBI | ECM Glycoproteins | 74.4 | 6.8 | 4 | 8.83 |
Serum albumin | ALB | Others | 69.2 | 5.8 | 3 | 12.60 |
Olfactomedin-like protein 3 | OLFML3 | Others | 45.9 | 6.2 | 2 | 7.73 |
Lumican | LUM | Proteoglycans | 38.7 | 5.9 | 2 | 8.65 |
Fibulin-5 | FBLN5 | ECM Glycoproteins | 50.1 | 4.6 | 2 | 5.10 |
Collagen alpha-1(I) chain | COL1A1 | Collagen | 138.9 | 5.6 | 2 | 3.53 |
Protein-lysine 6-oxidase | LOX | ECM Regulators | 29.1 | 6.0 | 2 | 13.30 |
Pigment epithelium-derived factor | SERPINF1 | ECM Regulators | 46.2 | 6.6 | 2 | 7.00 |
Tropomyosin 1 | TPM1 | Actin-related proteins | 32.7 | 4.7 | 2 | 9.90 |
Desmin | DES | Unclassified | 53.5 | 5.2 | 2 | 6.00 |
Deoxyribonuclease-1 | DNASE1 | Unclassified | 31.3 | 5.3 | 2 | 11.40 |
Thrombospondin-1 | THBS1 | ECM Glycoproteins | 129.5 | 4.7 | 1 | 1.37 |
Gelsolin | GSN | Others | 80.7 | 5.5 | 1 | 1.50 |
Asporin | ASPN | Proteoglycans | 42.1 | 9.2 | 1 | 5.70 |
Collagen alpha-2(I) chain | COL1A2 | Collagen | 129.0 | 9.2 | 1 | 1.60 |
Tumor necrosis factor alpha-induced protein 8-like protein 1 | TNFAIP8L1 | Unclassified | 20.9 | 9.7 | 1 | 5.90 |
Tissue factor pathway inhibitor 2 | TFPI2 | Others | 26.7 | 9.1 | 1 | 2.60 |
Protein disulfide-isomerase | P4HB | Others | 56.8 | 4.8 | 1 | 3.10 |
Glial fibrillary acidic protein | GFAP | Unclassified | 49.5 | 5.4 | 1 | 2.30 |