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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Rapid recovery of male cats with postrenal acute kidney injury by treating with allogeneic adipose mesenchymal stem cell-derived extracellular vesicles

Fig. 4

Potential targets of ADMSCEVs in the treatment of PR-AKI. A KEGG pathway analysis of significantly upregulated metabolites (annotated from positive ion features) in PR-AKI cats compared to normal cats. The metabolites enriched in the pathways with significant difference are listed on the right. P value < 0.05. B KEGG pathway analysis of significantly downregulated metabolites (annotated from positive ion features) in ADMSCEVs-treated cats compared to PR-AKI cats. The metabolites enriched in the pathways with significant difference are listed on the right. P value < 0.05. Common metabolites enriched in upregulated (A) and downregulated (B) pathways are marked with an asterisk. C KEGG pathway analysis of significantly upregulated metabolites (annotated from negative ion features) in PR-AKI cats compared to normal cats. D KEGG pathway analysis of significantly downregulated metabolites (annotated from negative ion features) in ADMSCEVs-treated cats compared to PR-AKI cats. Common metabolites enriched in upregulated (C) and downregulated (D) pathways are marked with an asterisk. E Heatmap showing the expression pattern of six metabolites as potential targets for ADMSCEVs treatment of PR-AKI

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Stem Cell Research & Therapy

ISSN: 1757-6512