Fig. 8

CD45⁺ staining of kidneys from transplanted mice: A Immunostaining of IPCs transplanted under the renal capsule of a diabetic humanized mouse with anti-CD45⁺ antibody. There were very few CD45⁺ cells. The yellow arrow inside the high magnification inset points to a CD45⁺ cell (brown). B Immunostaining of IPCs transplanted under the renal capsule of a normal nondiabetic animal with anti-CD45 antibody. There were few CD45⁺ cells. The yellow arrows inside the high magnification inset point to CD45⁺ cells (brown). C Immunostaining of a cross section of a kidney from a normal animal that was not transplanted. Immunostaining with an anti-CD45 antibody showing the absence of CD45⁺ cells. D Positive control: Cross section of a lymph node. Immunostaining with an anti-CD45 antibody showed a large number of CD45⁺ cells (brown)