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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia/reperfusion-induced acute kidney injury by regulating macrophages polarization

Fig. 1

Effect of MSCs-Exo-IDO on renal functions in IRI mouse model. A The protein content of IDO in MSCs-Exo-NC or MSCs-Exo-IDO was firstly detected by Western Blot (n = 3). B Quantization diagram of panel A as shown in the right. Then, IRI mouse model was established. IRI mice were challenged with MSCs-Exo-NC or MSCs-Exo-IDO. Next, serum was obtained from different group mice on days 0, 1, 3 and 7 after IRI. BUN C and Scr D contents were detected by the corresponding ELISA kits (n = 3/group, the results for the same mice at each time). E Kidney tissues were collected from the four groups on day 1, 3 and 7 after IRI (n = 3/group at each time). Kidney tissues in different groups were obtained and histopathology was monitored by HE staining. Arrowheads indicated the damaged tubular. The line chart is presented by Means ± SD, and the statistical analysis was performed using one-way ANOVA. **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512