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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia/reperfusion-induced acute kidney injury by regulating macrophages polarization

Fig. 2

Role of MSCs-Exo-IDO on renal tubular cell apoptosis in IRI mice. A Kidney tissues were collected from the four groups on day 3 after IRI (n = 3/group). Apoptotic cells were determined by TUNEL staining assay, and cell-labeled brown color were considered as the apoptotic renal tubular cells. Arrowheads indicated the TUNEL-positive cells. B Quantization diagram of TUNEL signal-positive cells as shown in the right. C Protein levels of pro-caspase3 and cleaved caspase3 were detected by WB assay in kidney tissues collected from day1, 3 and 7 after IRI (n = 3/group at each time). D Quantization diagram of cleaved caspase3 as shown in the right. Means ± SD was used for histogram presentation. **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512