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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosome from indoleamine 2,3-dioxygenase-overexpressing bone marrow mesenchymal stem cells accelerates repair process of ischemia/reperfusion-induced acute kidney injury by regulating macrophages polarization

Fig. 4

Effect of MSCs-Exo-IDO on renal fibrosis in IRI mouse model. A Kidney tissues were harvested from the four groups on day 28 after IRI (n = 3/group). Kidney tissues in different groups were obtained and histopathology was monitored by Masson staining. Arrowheads indicated the collagen deposition and fibrotic lesions. B Quantization diagram of panel A as shown in the right. C Western Blot was used to detect the expression of α-SMA, collagen I and collagen III in the above kidney tissues (n = 3/group). D Quantization diagram of panel C as shown in the right. The histogram is presented by Means ± SD. *P < 0.05; **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512