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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice

Fig. 2

AEC-SC reduced the inflammation of back skin in IMQ-induced psoriasis-like mice. a Immunostaining of back skin tissue with a Gr-1 antibody and the representative images are shown. Scale bar: 50 μm. b Qualification of the number of Gr-1 positive cells of lesion skin tissue per field in different groups. At least 6 fields for each group were counted and at least three mice were used in each group. **P < 0.01, ***P < 0.001. c Flow cytometry analysis of IL7-producing δγ T cells (IL-17+ γδ T cells) and IL-17-producing γδ TCR negative cells (Th17 cells). d Quantification of IL-17+ δγ T cells and Th17 cells. e The relative mRNA levels of IL-1β, IL-17A, IL-23, IL-6, TNFα, CXCL1, and CCL20 in the lesion skin of mice in each group. The mRNA levels of genes in CON group were set as 1 and the data are expressed as the mean ± SEM, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001

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