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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice

Fig. 5

Anti-inflammatory factor IL-1ra is necessary for AEC-SC-mediated immunosuppression on skin inflammation of IMQ-induced psoriasis-like mice. a Immunostaining of back skin tissues with a Gr-1 antibody and the representative images are shown. Scale bar: 50 μm. b Qualification of the number of Gr-1 positive cells of back skin for per field in different groups. c Flow cytometry analysis of IL-17-producing γδ T cells and Th17 Cell. d Quantification of IL-17+ γδ T cells and Th17 cells. e, f The relative mRNA levels of IL-1β, IL-17A, IL-23, TNF-a, IL-6, CXCL1 and CCL20 in the lesion skin tissue of mice in each group by real-time PCR analysis. *P < 0.05, **P < 0.01 and ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512