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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment

Fig. 6

MiR-543 inhibitor suppressed the osteogenic differentiation capacity of PDLSCs enhanced by circBIRC6 downregulation under the inflammatory microenvironment. A ALP staining of PDLSCs with indicated modifications. B ARS staining of mineralized nodules formed by PDLSCs with indicated treatments. C–E qRT-PCR, WB and immunofluorescence staining were performed to detect the changes in osteogenic differentiation makers in PDLSCs with indicated modifications. Scale bar: 20 μm. Data are presented as the mean ± SD (***P < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512