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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression

Fig. 2

Two-dose intravenous administration of hUCMSCs increases the frequency of circulating and heart Tregs and IDO expression in the hearts of DCM rats. A, B Representative flow cytometry dot plots of CD4+CD25+foxp3+ Tregs in peripheral blood and quantitative analysis. C, D Representative flow cytometry dot plots and quantitative analysis of Tregs in the hearts of DCM rats at 8 weeks post-induction. E, F Western blot and quantitative analysis of IDO expression. Data are presented as mean ± SEM of each group (N = 3–5 rats per group) from at least two independent experiments. *P < 0.05, **P < 0.001, ***P < 0.001 by one-way ANOVA

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Stem Cell Research & Therapy

ISSN: 1757-6512