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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Infusion of two-dose mesenchymal stem cells is more effective than a single dose in a dilated cardiomyopathy rat model by upregulating indoleamine 2,3-dioxygenase expression

Fig. 6

IDO-OE hUCMSC administration reduces the degrees of myocardial fibrosis in DCM rats. A Hematoxylin and eosin (H&E) staining of morphological changes in rat heart samples, scale bar = 100 μm. B Sirius Red staining of collagen fibers in rat heart specimens, scale bar = 100 μm. C Quantitative analysis of fibrosis severity, based on Sirius Red staining. D, E Western blot analysis of MMP2, MMP9, and α-SMA expression in heart tissues of rats. F RT-qPCR analyses of the relative mRNA transcripts of genes related to fibrosis. Data are mean ± SEM of each group (N = 3–5 rats per group) from at least two independent experiments. *P < 0.05, **P < 0.001, ***P < 0.001 by one-way ANOVA

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Stem Cell Research & Therapy

ISSN: 1757-6512