Fig. 6

Changes in the amniotic fluid microenvironment after transplantation of BDNF-BMSCs. A. Protein array analysis of amniotic fluid with BMSC transplantation (n = 3, samples: C1, C2, C3) and BDNF-BMSCs transplantation (n = 3, samples: CB1, CB2, CB3). Upregulated proteins (fold change > 3) with p < 0.05 are shown in the cluster analysis. B. Interaction network of differentially expressed proteins generated by STRING database. The colors of the inside nodes indicate that the proteins come from different biological processes, including negative regulation of neuronal apoptosis (red, GO: 0,043,524), positive regulation of cell migration (blue, GO: 0,030,335), and wound healing (green, GO: 0,042,060), while the proteins that were not involved in the above-mentioned three processes are marked in gray. The thickness of the lines connecting the nodes indicates the strength of data support